Calcium Carbonate → HCID 10368686, compound

HRID 1987185Notes

Reaction equation

HRID 1987185 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:21]=[CH:20][C:19]([S:22]([NH:25][P:26](=[O:29])([OH:28])[OH:27])(=[O:24])=[O:23])=[CH:18][CH:17]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1.C([O-])([O-])=O.[Ca+2:34]>O>[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:17]=[CH:18][C:19]([S:22]([NH:25][P:26](=[O:27])([O-:28])[O-:29])(=[O:23])=[O:24])=[CH:20][CH:21]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1.[Ca+2:34]

Participants

4

Reactant 2

HCID 10112Calcium CarbonateHCID 9890518HCID 9890518, compound

Product 1

HCID 10368686HCID 10368686, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidic acid (0.3 g, 0.65 mmol) (obtained in example 6) and CaCO3 (66 mg, 0.66 mmol) in H2O (38 mL) was stirred at room temperature for 1 h. A white solid was formed, which was collected by filtration, washed with H2O and dried, to afford the title compound of the example in 71% yield.

Workup

  1. customA white solid was formed
  2. filtrationwhich was collected by filtration
  3. washwashed with H2O
  4. customdried

Sources & evidence

ORD record
ord-c4911810d5db43e0a95416db5ec5fbe4
Source dataset
uspto-grants-2009_06
Patent number
US07550497B2

Reaction notes

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