Acetate-hydrochloric acid → HCID 57441095, compound

HRID 1987218Notes

Reaction equation

HRID 1987218 reaction equation
[F:1][C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:4][CH:3]=1.[ClH:17].CC(O)=O>>[ClH:17].[F:1][C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][NH2:9])[CH2:4][CH:3]=1

Participants

3

Reactant 2

HCID 22641269Acetate-hydrochloric acidHCID 57441094HCID 57441094, compound

Product 1

HCID 57441095HCID 57441095, compound

Procedure

tert-Butyl [(4-fluorocyclohex-3-en-1-yl)methyl]carbamate (1.62 g, 7.06 mmol) was stirred in 25 mL of 1M HCl/AcOH at rt for 2 h. The solvent was evaporated and the product was precipitated in ether, filtered and dried under vacuum. Yield: 1.13 g (97%). 1H NMR (400 MHz, METHANOL-D4) δ 1.44-1.53 (m, 1 H), 1.80-1.89 (m, 2 H), 1.90-1.98 (m, 1 H), 2.16-2.23 (m, 2 H), 2.26-2.34 (m, 1 H), 2.88 (d, J=6.25 Hz, 2 H), 5.12-5.19 (m, 1 H).

Workup

  1. customThe solvent was evaporated
  2. customthe product was precipitated in ether
  3. filtrationfiltered
  4. customdried under vacuum

Sources & evidence

ORD record
ord-c39b5f74b6d34518a6380375295a2d7b
Source dataset
uspto-grants-2009_06
Patent number
US07550495B2

Reaction notes

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