HCID 672599, compound → HCID 25013775, compound

Participants

Reaction Steps

(R)-2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-N-[1-(2,4-difluorophenyl-ethyl]benzamide. 2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)benzoic acid was coupled with (R) 1-(2,4-difluorophenyl)-ethylamine (see EXAMPLE 39), and the product was purified, as described in EXAMPLE 7 to provide the title compound. MS (ESI): neg. ion m/z 473 [M−H]−. HPLC (reversed-phase): RT=9.64 min). 1H NMR (400 MHz, CDCl3): 11.38 (s, 1H), 8.32 (dd, J=7.1, 1.0 Hz, 1H), 8.16 (dd, J=8.8, 1.0 Hz, 1H), 7.68 (m, 1H), 7.65 (dd, J=8.8, 7.0 Hz, 1H), 7.30 (m, 3H), 6.98 (m, 1H), 6.88 (m, 1H), 6.85 (m, 1H), 6.40 (bd, J=7.6 Hz, 1H), 5.32 (m, 1H), 1.54 (d, J=6.8 Hz, 3H).

Provenance & Evidence