HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(6-Methyl-3-pyridyloxy)-2-methylpropionic Acid → N-[2,3-Bis(4-Chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(6-Methyl-3-pyridyloxy)-2-methylpropionic Acid | HCID 22270403 | — |
| Reactant | 2,3-Bis(4-chlorophenyl)-1-methylpropylamine hydrochloride | HCID 22270427 | — |
| Product | N-[2,3-Bis(4-Chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide | HCID 22270440 | — |
Reaction Steps
The title compound was prepared by reacting 2-(6-methyl-3-pyridyloxy)-2-methylpropionic acid (Step B, 75 mg, 0.63 mmol) with 2-amino-3,4-bis(4-chlorophenyl)butane hydrochloride salt (Diastereomer α, Reference Example 1) (0.23 g, 0.63 mmol) following the procedure described in Example 62-63. LC-MS: m/e 471 (M+H)+ (3.1 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550489B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-9aeea9c82c914ee5b3f7bacd2def9e6c |
| Source note | uspto-grants-2009_06 |