HCID 24895128, compound → HCID 24894908, compound

HRID 1987421Notes

Reaction equation

HRID 1987421 reaction equation
[ClH:1].Cl.[CH3:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][C@H:24]2O)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:22])([F:21])[F:20])[CH:13]=2)[CH2:6][CH2:5]1.Cl.Cl.N1(C[C@H](C2(O)CCCCC2)C2C=CC=C([O:46]C(F)(F)F)C=2)CCNCC1>>[ClH:1].[ClH:1].[CH3:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:10][C@H:11]([C:23]2([OH:46])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:20])([F:21])[F:22])[CH:13]=2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 24895128HCID 24895128, compoundHCID 86600331HCID 86600331, compound

Product 1

HCID 24894908HCID 24894908, compound

Procedure

In an analogous manner to Example 24, 1-{(1R)-2-(4-methylpiperazin-1-yl-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from, 1-{(1R)-2-piperazin-1-yl-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol (See Example 244). HRMS: calcd for C20H29F3N2O2+H, 387.22594. found (ESI, [M+H]+), 387.2269.

Sources & evidence

ORD record
ord-c153ae044ea74c779cf7289b725845e2
Source dataset
uspto-grants-2009_06
Patent number
US07550485B2

Reaction notes

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