HCID 68853346, compound → HCID 68855451, compound

HRID 1987430Notes

Reaction equation

HRID 1987430 reaction equation
Cl.Cl.C(OC1C=CC([CH:17]([N:26]2[CH2:30][CH2:29][C@@H:28]([N:31]([CH3:33])[CH3:32])[CH2:27]2)[CH2:18][C:19]2([OH:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=CC=1[Cl:34])C1C=CC=CC=1.Cl.Cl.N[C@@H]1CCN(CC(C2(O)CCCCC2)[C:45]2[CH:50]=[CH:49][C:48]([O:51][CH2:52][C:53]3[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=3)=[C:47]([Cl:59])[CH:46]=2)C1>>[ClH:34].[ClH:59].[CH2:52]([O:51][C:48]1[CH:49]=[CH:50][C:45]([CH:18]([C:19]2([OH:25])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[CH2:17][N:26]2[CH2:30][CH2:29][C@@H:28]([N:31]([CH3:33])[CH3:32])[CH2:27]2)=[CH:46][C:47]=1[Cl:59])[C:53]1[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=1

Participants

3

Reactant 2

HCID 68853346HCID 68853346, compoundHCID 86600337HCID 86600337, compound

Product 1

HCID 68855451HCID 68855451, compound

Procedure

In an analogous manner to Example 36, 1-{-[4-(benzyloxy)-3-chlorophenyl]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from 1-{2-[(3R)-3-aminopyrrolidin-1-yl]-1-[4-(benzyloxy)-3-chlorophenyl]ethyl}cyclohexanol (See Example 383). MS (ES) m/z 457.1; HRMS: calcd for C27H37ClN2O2+H+, 457.26163. found (ESI, [M+H]+), 457.2608.

Sources & evidence

ORD record
ord-601ab5c3a3234bcbb175770c7ba62e53
Source dataset
uspto-grants-2009_06
Patent number
US07550485B2

Reaction notes

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