HCID 68853141, compound → HCID 68853773, compound

HRID 1987433Notes

Reaction equation

HRID 1987433 reaction equation
[ClH:1].Cl.OC1([C:10]2(O)[CH:15]=[CH:14][CH:13]=[CH:12][C:11]2([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]2)[O:16]C(F)(F)F)CCCCC1.Cl.Cl.OC1(C([C:48]2[CH:53]=[CH:52][C:51]([OH:54])=[C:50]([O:55][C:56]([F:59])([F:58])[F:57])[CH:49]=2)CN2CCNCC2)CCCCC1>>[ClH:1].[ClH:1].[OH:16][C:11]1([CH:21]([C:48]2[CH:53]=[CH:52][C:51]([OH:54])=[C:50]([O:55][C:56]([F:57])([F:59])[F:58])[CH:49]=2)[CH2:22][N:23]2[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]2)[CH2:10][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 68853141HCID 68853141, compoundHCID 86599406HCID 86599406, compound

Product 1

HCID 68853773HCID 68853773, compound

Procedure

In an analogous manner to Example 24, 4-[1-(1-hydroxycyclohexyl)-2-(4-methylpiperazin-1-ylethyl]-2-(trifluoromethoxy)phenol dihydrochloride was prepared from 4-[1-(1-hydroxycyclohexyl)-2-piperazin-1-ylethyl]-2-(trifluoromethoxy)phenol dihydrochloride (see Example 400). MS (ESI) m/z 403; HRMS: calcd for C20H29F3N2O3+H+, 403.22030. found (ESI, [M+H]+), 403.2201.

Sources & evidence

ORD record
ord-bad6d496f2454ac9896ccdaf6c7a7ef7
Source dataset
uspto-grants-2009_06
Patent number
US07550485B2

Reaction notes

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