HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68854741, compound → 1-(1-[3-fluoro-4-[(4-methylbenzyl)oxy]phenyl}-2-piperazin-1-ylethyl)cyclohexanol Dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68854741 | HCID 68854741 | — |
| Reactant | 1-[1-(3-Fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride | HCID 86599057 | — |
| Product | 1-(1-[3-fluoro-4-[(4-methylbenzyl)oxy]phenyl}-2-piperazin-1-ylethyl)cyclohexanol Dihydrochloride | HCID 68855332 | — |
Reaction Steps
In an analogous manner to Example 1, step 2 1-[1-(3-fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[(3-fluoro-4-{[4-(methyl)benzyl]oxy}phenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate. MS (ESI) m/z 427; HRMS: calcd for C26H35FN2O2+H+, 427.27553. found (ESI, [M+H]+), 427.2776.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550485B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-f79c5b9563844de8bf416754460b2c40 |
| Source note | uspto-grants-2009_06 |