HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-(3-Methoxybenzyl)benzenethiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | (3-Methoxyphenyl)(2-(2,4,6-trimethoxybenzylthio)phenyl)methanol | HCID 68643652 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 2-(3-Methoxybenzyl)benzenethiol | HCID 68643620 | 77% |
Reaction Steps
0.288 g (3-methoxyphenyl)(2-(2,4,6-trimethoxybenzylthio)phenyl)methanol (K) (0.68 mmol) was treated with a solution of triethylsilane:TFA:DCM 0.3 ml:1 ml:10 ml. The mixture was stirred overnight at ambient temperature before the addition of water. The mixture was extracted with DCM, brine, dried over magnesium sulfate and concentrated. Flash silica chromatography (hexane:ethyl acetate 90:10) afforded 0.12 g product (0.52 mmol, 77% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550505B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-e4627e0714af42b181261cc2b0b9c2b4 |
| Source note | uspto-grants-2009_06 |