HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-bromo-4-methyl- → N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-bromo-4-methyl- | HCID 82187 | — |
| Reactant | Methyl 4-((4-methylpiperazin-1-yl)methyl)benzoate | HCID 782222 | — |
| Product | N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide | HCID 10309714 | — |
Reaction Steps
Another process, depicted in Scheme 2, involves reacting 3-bromo-4-methyl-aniline with 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid methyl ester to obtain N-(3-bromo-4-methyl-phenyl)-4-(4-methyl-piperazin-1-ylmethyl)-benzamide. The latter is reacted with 4-(3-pyridyl)-2-pyrimidine amine (which is obtained by reacting cyanamide with 3-dimethylamino-1-pyridin-3-yl-propenone) to obtain imatinib.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550591B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-f60f8ac9bc7f4f63bb0978390afe8a46 |
| Source note | uspto-grants-2009_06 |