Benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate → 1-(Cyclopropylcarbonyl)piperazine

HRID 1987551Notes

Reaction equation

HRID 1987551 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)=[O:5])[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 23069850Benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate

Product 1

HCID 20642351-(Cyclopropylcarbonyl)piperazineYield 97.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

In 100 mL of ethanol was dissolved benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate (3.00 g, 10.4 mmol), and 1.5 g of 10% palladium-carbon was added thereto, followed by stirring at room temperature under hydrogen atmosphere overnight. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (1.50 g, 97.3%) as a colorless oil.

Workup

  1. additionwas added
  2. customThe palladium-carbon was removed by filtration
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-859d2ad4d2aa42ddb19d0770c7f74148
Source dataset
uspto-grants-2009_06
Patent number
US07550503B2

Reaction notes

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