HCID 23069873, compound → HCID 22047906, compound

HRID 1987556Notes

Reaction equation

HRID 1987556 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:11][CH2:10][CH2:9][N:8](C(OCC3C=CC=CC=3)=O)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[CH:1]1([CH2:4][N:5]2[CH2:11][CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 23069873HCID 23069873, compound

Product 1

HCID 22047906HCID 22047906, compoundYield 104.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The resulting benzyl 4-(cyclopropylmethyl)homopiperazin-1-carboxylate (2.5 g) was dissolved in 50 mL of ethanol, 10% palladium-carbon (500 mg) was added, and the reaction mixture was stirred at room temperature under hydrogen atmosphere (1 atm) for 12 hours. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (1.4 g) as a colorless oil.

Workup

  1. customThe palladium-carbon was removed by filtration
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-45645ac150da4c529e66e45ec06dfba4
Source dataset
uspto-grants-2009_06
Patent number
US07550503B2

Reaction notes

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