Hydrochloric Acid → HCID 24765378, compound

Participants

Reaction Steps

A solution of lithium borohydride (2.0 M in THF, 0.34 mL) was added to a solution of (2S,3S)-2-(4-chloro-benzenesulfonylamino)-4,4,4-trifluoro-3-methyl-butyric acid ethyl ester (126 mg, 0.34 mmol) in THF (5 mL) and stirred for 12 h. Careful addition of 2N HCl (aq) was performed until pH<2. Organic solvent was removed in vacuo. The aqueous layer was extracted with EtOAc (2×20 mL) and organic layers were combined and washed with brine. The organic layer was dried over Na2SO4 and solvent removed in vacuo. The crude solid was purified by flash chromatography (20% EtOAc/hexanes) to provide a white solid (80 mg) in 71 % yield. Mass Spectrum (−ESI): 330.0 [M−H]−.

Provenance & Evidence