Lithium borohydride → 4-Chloro-N-[4,4,4-trifluoro-1-hydroxymethyl-2-(2,2,2-trifluoroethyl)-butyl]-benzenesulfonamide

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Reaction Steps

A solution of 2-(4-chloro-benzenesulfonylamino)-5,5,5-trifluoro-3-(2,2,2-trifluoroethyl)-pentanoic acid methyl ester (120 mg, 0.27 mmol) in THF (5 mL) was treated with LiBH4 (2M THF, 0.3 mL) for 18 hours at 25° C. The reaction was carefully quenched by the addition of 2M HCl and the organic solvent removed in vacuo. The aqueous layer was extracted with EtOAc (2×10 mL). The organic layers were combined, dried over Na2SO4 and evaporated to afford a crude oil which was purified by flash chromatography, eluting with 30:70 EtOAc:hexanes, to provide the title compound as a white solid (75 mg) in 67% yield. Mass Spectrum (−ESI): 412.0 (M−H)−.

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