2-Mercaptopyridine → HCID 178434129, compound

HRID 1987600Notes

Reaction equation

HRID 1987600 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]/[C:4](=[C:12]2/[C:13]([CH3:18])=[N:14][NH:15][C:16]/2=[O:17])/[CH:3]=1.[CH:19]1[CH:25]=[CH:24][NH:23][C:21](=[S:22])[CH:20]=1>>[CH3:18][C:13]1=[N:14][NH:15][C:16](=[O:17])/[C:12]/1=[C:4]1\[NH:5][C:6]2[C:11]([C:2]([S:22][C:21]3[CH:20]=[CH:19][CH:25]=[CH:24][N:23]=3)=[CH:3]\1)=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 27236982-MercaptopyridineHCID 178434119HCID 178434119, compound

Product 1

HCID 178434129HCID 178434129, compound

Procedure

The title compound was prepared from (Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-methyl-1H-pyrazol-5(4H)-one and 2-thiopyridine using the procedure described in Example 6. 1H NMR (400 MHz, DMSO-D6) δ ppm 2.31 (s, 3H) 7.40 (dd, J=7.20, 4.93 Hz, 1H) 7.55 (t, J=7.58 Hz, 2H) 7.73 (s, 1H) 7.77-7.87 (m, 2H) 7.96 (d, J=8.59 Hz, 1H) 8.06 (d, J=8.08 Hz, 1H) 8.58 (d, J=3.79 Hz, 1H); ESI-MS: m/z calc'd for C18H14N4OS 334.09. found 335.2 (M+H)+.

Sources & evidence

ORD record
ord-c038617896d14076b38816086b86f2bc
Source dataset
uspto-grants-2009_06
Patent number
US07550598B2

Reaction notes

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