HCID 178434119, compound → HCID 178434130, compound

HRID 1987601Notes

Reaction equation

HRID 1987601 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]/[C:4](=[C:12]2/[C:13]([CH3:18])=[N:14][NH:15][C:16]/2=[O:17])/[CH:3]=1.[SH:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][N:21]=1>>[CH3:18][C:13]1=[N:14][NH:15][C:16](=[O:17])/[C:12]/1=[C:4]1\[NH:5][C:6]2[C:11]([C:2]([S:19][C:20]3[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][N:21]=3)=[CH:3]\1)=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 178434119HCID 178434119, compoundHCID 1785245186-sulfanylpyridine-3-carboxylic acid

Product 1

HCID 178434130HCID 178434130, compound

Procedure

The title compound was prepared from (Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-methyl-1H-pyrazol-5(4H)-one and 6-mercaptonicotinic acid using the procedure described in Example 6. 1H NMR (400 MHz, DMSO-D6) δ ppm 2.49 (s, 3H) 7.30 (s, 1H) 7.50 (t, J=7.58 Hz, 1H) 7.72-7.82 (m, 1H) 7.99 (t, J=9.09 Hz, 2H) 8.11 (dd, J=8.34, 1.77 Hz, 1H) 8.17 (s, 1H) 8.88 (d, J=1.52 Hz, 1H); ESI-MS: m/z calc'd for C19H14N4O3S 378.08. found 379.2 (M+H)+.

Sources & evidence

ORD record
ord-d7eab088d90d4c6f843c2f2317f28413
Source dataset
uspto-grants-2009_06
Patent number
US07550598B2

Reaction notes

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