反应详情

温度

180 °C

(Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-isopropyl-1H-pyrazol-5(4H)-one (0.029 g, 0.089 mmol) was dissolved in ethanol (1 mL) and 4-acetamidothiophenol (0.016 g, 0.094 mmol) was added. The reaction mixture was heated to 180° C. using a microwave reactor for 30 minutes. The mixture was then concentrated and purified by LC-MS to give Example 19. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.96 (d, J=6.82 Hz, 6H) 2.13 (s, 3H) 2.53 (bs, 1H) 6.65 (s, 1H) 7.68-7.70 (m, 3H) 7.86-7.97 (m, 3H) 8.02 (s, 1H) 8.20 (d, J=8.34 Hz, 1H) 10.43 (s, 1H); ESI-MS: m/z calc'd for C23H22N4O2S 418.51. found 419.3 (M+H)+.

1. customfor 30 minutes
2. concentrationThe mixture was then concentrated
3. custompurified by LC-MS
4. customto give Example 19