4-Aminothiophenol → HCID 178440358, compound

HRID 1987608Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]/[C:4](=[C:12]2/[C:13]([CH:18]([CH3:20])[CH3:19])=[N:14][NH:15][C:16]/2=[O:17])/[CH:3]=1.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([SH:28])=[CH:24][CH:23]=1>>[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5]/[C:4](=[C:12]3/[C:13]([CH:18]([CH3:20])[CH3:19])=[N:14][NH:15][C:16]/3=[O:17])/[CH:3]=2)=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 145104-Aminothiophenol

HCID 178440351HCID 178440351, compound

Product 1

HCID 178440358HCID 178440358, compound

Procedure

Example 20 was synthesized from (Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-isopropyl-1H-pyrazol-5(4H)-one and 4-aminothiophenol according to the procedure described in Example 19. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.00 (bs, 6H) 3.33 (bs, 1H) 5.87 (s, 1H) 6.78 (d, J=8.34 Hz, 2H) 7.31 (d, J=8.34 Hz, 2H) 7.52 (bs, 1H) 7.77 (bs, 1H) 8.03 (d, J=8.34 Hz, 1H); ESI-MS: m/z calc'd for C21H20N4OS 376.47. found 377.2 (M+H)+.

Sources & evidence

ORD record: ord-6287a215fb9b4356a25c47a63e349b1a
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550598B2

Reaction notes

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