反应详情

温度

180 °C

(Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-propyl-1H-pyrazol-5(4H)-one (0.045 g, 0.013 mmol) was dissolved in ethanol (1.5 mL) and 4-aminothiophenol (0.017 g, 0.013 mmol) was added. The reaction mixture was heated to 180° C. using a microwave reactor for 5-10 minutes. The mixture was then concentrated and purified by LC-MS to give Example 25. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.78 (t, J=7.45 Hz, 3H) 1.30-1.40 (m, 2H) 2.22-2.32 (m, 2H) 6.77 (d, J=8.34 Hz, 3H) 7.33 (d, J=8.59 Hz, 2H) 7.60 (t, J=7.33 Hz, 1H) 7.82-7.92 (m, 2H) 8.12 (d, J=8.08 Hz, 1H); ESI-MS: m/z calc'd for C21H20N4OS 376.47. found 377.2 (M+H)+.

1. customfor 5-10 minutes
2. concentrationThe mixture was then concentrated
3. custompurified by LC-MS
4. customto give Example 25