Isobutyryl chloride → HCID 178440382, compound

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Reaction Steps

The title compound was synthesized using (Z)-4-(4-(4-aminophenylthio)quinolin-2(1H)-ylidene)-3-propyl-1H-pyrazol-5(4H)-one and isobutyryl chloride in THF according to the procedure described in the synthesis of Example 26. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.69 (t, J=7.33 Hz, 3H) 1.13 (d, J=6.82 Hz, 6H) 1.27-1.37 (m, J=7.42, 7.42, 7.42, 7.42, 7.20 Hz, 2H) 2.20 (t, J=7.20 Hz, 2H) 2.65 (dt, J=13.58, 6.73 Hz, 1H) 6.73 (s, 1H) 7.62 (t, J=7.58 Hz, 1H) 7.68 (d, J=8.34 Hz, 2H) 7.83-7.93 (m, 4H) 8.13 (d, J=8.08 Hz, 1H) 10.22 (s, 1H); ESI-MS: m/z calc'd for C25H26N4O2S 446.56. found 447.1 (M+H)+.

Provenance & Evidence