反应详情

温度

170 °C

(Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-propyl-1H-pyrazol-5(4H)-one (0.03 g, 0.1 mmol) was dissolved in ethanol (1.5 mL) and di-tert-butyl 5-amino-3-oxo-1H-indazole-1,2(3H)-dicarboxylate (0.044 g, 0.12 mmol) was added. The reaction mixture was heated to 170° C. using a microwave reactor for 30 minutes. The mixture was concentrated and purified by LC-MS to give the title compound of Example 51. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.51 (t, J=6.95 Hz, 3H) 1.26-1.33 (m, 2H) 2.39 (dd, J=9.09, 3.28 Hz, 2H) 6.41 (s, 1H) 7.38 (dd, J=8.72, 1.64 Hz, 1H) 7.45-7.51 (m, 1H) 7.67-7.73 (m, 2H) 7.90-7.98 (m, 2H) 8.59 (d, J=7.58 Hz, 1H) 10.49 (s, 1H) 11.79 (s, 1H); ESI-MS: m/z calc'd for C22H20N6O2 400.43. found 401.3 (M+H)+.

1. customfor 30 minutes
2. concentrationThe mixture was concentrated
3. custompurified by LC-MS