反应详情

3-Cyclopropyl-1H-pyrazol-5(4H)-one (0.03 g, 0.27 mmol) and isoquinoline N-oxide (0.04 g, 0.27 mmol) were stirred in acetic anhydride (0.5 mL) for 30-40 minutes. The reaction mixture was concentrated and purified by LC-MS to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.78-0.86 (m, 4H) 1.77-1.86 (m, 1H) 7.91 (t, J=7.71 Hz, 1H) 8.10 (t, J=7.58 Hz, 1H) 8.26 (d, J=8.59 Hz, 3H) 8.58 (d, J=6.57 Hz, 1H); ESI-MS: m/z calc'd for C15H13N3O 251.28. found 252.2 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. custompurified by LC-MS