HCID 12179943, compound → HCID 57723940, compound

Participants

Reaction Steps

(2R,3R,4S,5S)-3-acetoxy-4,5-dihydroxy-tetrahydropyran-2-carboxylic acid ethyl ester (300 mg, 1.2 mmol) was dissolved in DMF (5 ml) and the solution was subjected to microwave irradiation at 150° C. for 4H. After cooling, the solvent was removed in vacuo. The crude product was purified by flash chromatography with 20% EtOAc-hexane to give (−)-(1R,4S,5S,8R)-8-acetoxy-4-hydroxy-2,6-dioxa-bicyclo[3.2.1]octan-7-one.

Provenance & Evidence