Hydrochloric Acid → 1,5-anhydro-D-mannitol

Participants

Reaction Steps

To a solution of (−)-(4aR,7R,8R,8aS)-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol (42 mg, 0.21 mmol) in MeOH (2 mL) was added a solution of methanolic HCl (0.6 mL, prepared from 0.5 mL conc. HCl in 30 mL of MeOH). The solution was stirred for 1H at ambient temperature and concentrated in vacuo.

Provenance & Evidence