HCID 87614901, compound → HCID 87615001, compound

HRID 1987698Notes

Reaction equation

HRID 1987698 reaction equation
C1C=CC(C([S+]([O-])CC(N)=[O:17])C2C=CC=CC=2)=CC=1.[CH:20]([S:33][C:34]([OH:36])=[O:35])([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH:20]([S@@:33]([C:34]([OH:36])=[O:35])=[O:17])([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 87614901HCID 87614901, compoundHCID 178514057HCID 178514057, compound

Product 1

HCID 87615001HCID 87615001, compound

Procedure

In another aspect, a method of preparing an (+)-(S)-enantiomer of modafinil is disclosed. The method includes subjecting benzhydrylsulfanyl carboxylic acid to an oxidation reaction using Beauveria bassiana to obtain (S)-benzhydrylsulfinyl carboxylic acid and subjecting the (S)-benzhydrylsulfinyl carboxylic acid to an amidation reaction using Bacillus subtilis to obtain (+)-(S)-modafinil.

Workup

  1. customto an oxidation reaction

Sources & evidence

ORD record
ord-886b9be9a0f8481391a5b6ef1834c2b0
Source dataset
uspto-grants-2009_06
Patent number
US07553646B2

Reaction notes

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