7-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one → 7-[5-Chloro-4-(2-fluoro-6-methanesulfonyl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 198770Notes

Reaction equation

HRID 198770 reaction equation
[Cl:16][c:17]1[n:18][cH:19][c:20]([Cl:35])[c:21]([NH:23][c:24]2[c:25]([F:34])[cH:26][cH:27][cH:28][c:29]2[S:30](=[O:31])(=[O:32])[CH3:33])[n:22]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:14][cH:15]1)[NH:6][C:7](=[O:13])[CH2:8][CH2:9][C:10]2([CH3:11])[CH3:12]>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:14][cH:15]1)[NH:6][C:7](=[O:13])[CH2:8][CH2:9][C:10]2([CH3:11])[CH3:12])[c:17]1[n:18][cH:19][c:20]([Cl:35])[c:21]([NH:23][c:24]2[c:25]([F:34])[cH:26][cH:27][cH:28][c:29]2[S:30](=[O:31])(=[O:32])[CH3:33])[n:22]1

Participants

3

Reactant 2

HCID 578538307-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-oneHCID 86633988(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methanesulfonyl-phenyl)-amine

Product 1

HCID 672638907-[5-Chloro-4-(2-fluoro-6-methanesulfonyl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-c60f220fa19e4311aa7fe238565d433a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…