Tetrahydrofuran → HCID 68905334, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(3,3-dimethyl-but-1-ynyl)-1-(2-nitro-phenyl)-1H-pyrazole (20 g, 74 mmol), tetrahydrofurane (100 ml) and acetic acid (425 ml of a 5% aqueous solution) was heated to 80° C. Iron powder (66 g, 1.2 mol) was added in small portions at this temperature. The reaction mixture was heated for 5 hours to reflux. After cooling, it was poured onto ice and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over magnesium sulfate and evaporated, delivering Compound No. 5.030.r (20 g).

Provenance & Evidence