HCID 23514989, compound → HCID 20644301, compound

HRID 1987724Notes

Reaction equation

[CH3:1][Si:2]([CH3:52])([O:7][C@@H:8]1[C@H:12]([O:13][Si:14]([CH3:20])([CH3:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[C@@H:11]([CH2:21][O:22][Si:23]([CH3:29])([CH3:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[O:10][C@H:9]1[N:30]1[CH:38]=[N:37][C:36]2[C:31]1=[N:32][C:33]([C:40]1[CH:41]=[N:42][N:43]([CH2:45][C:46]3C=C[CH:49]=[CH:48][CH:47]=3)[CH:44]=1)=[N:34][C:35]=2[NH2:39])[C:3]([CH3:6])([CH3:5])[CH3:4].IC(C)CCCC1C=CNN=1.IC1C=CC(CC2C=CNN=2)=CC=1>>[CH3:52][Si:2]([CH3:1])([O:7][C@@H:8]1[C@H:12]([O:13][Si:14]([CH3:20])([CH3:19])[C:15]([CH3:18])([CH3:16])[CH3:17])[C@@H:11]([CH2:21][O:22][Si:23]([CH3:28])([CH3:29])[C:24]([CH3:27])([CH3:26])[CH3:25])[O:10][C@H:9]1[N:30]1[CH:38]=[N:37][C:36]2[C:31]1=[N:32][C:33]([C:40]1[CH:41]=[N:42][N:43]([CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[CH:44]=1)=[N:34][C:35]=2[NH2:39])[C:3]([CH3:4])([CH3:5])[CH3:6]

Participants

Reactant 3

HCID 23514989HCID 23514989, compound

HCID 178462439HCID 178462439, compound

HCID 178506544HCID 178506544, compound

Product 1

HCID 20644301HCID 20644301, compound

Procedure

Compound 14 was prepared in the manner of compound 11 substituting 4-iodo-pentylpyrazole for 4-iodo-benzylpyrazole to afford compound 14: 1H NMR(CDCl3) 0.00(s, 3H, CH3), 0.01(s, 3H, CH3), 0.04(s, 3H, CH3), 0.07 (s, 3H, CH3), 0.11 (s, 3H, CH3), 0.14 (s, 3H, CH3), 0.78 (s, 9H, t-bu), 0.80 (t, 3H), 0.83 (s, 9H, t-bu), 0.91 (s, 9H, t-bu), 1.25-1.40 (m, 4H), 1.85-1.95 (m, 2H), 3.82 (d, 1H), 4.08 (d, 1H), 4.20-4.28 (m, 3H), 4.32-4.34 (m, 1H), 4.55-4.57 (m, 1H), 5.35 (m, 2H), 5.70 (bs, 2H, D2O exchangeable), 6.08 (d, 1H), 7.28-7.40 (m, 5H), 8.05 (s, 1H), 8.15 (s, 1H), 8.20 (s, 1H).

Sources & evidence

ORD record: ord-201fb0aea68b4d41aabac9ac7a8ee037
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07553823B2

Reaction notes

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