Sodium Hydroxide → HCID 23118274, compound

Participants

Reaction Steps

To 2.5 g of 1-acetyl-4-(4-imidazol-1-ylphenyl)-4-hydroxypiperidine, 30 ml of concentrated hydrochloric acid was added, followed by heating at reflux for 4 hours. After the completion of the reaction, the reaction solution was cooled, neutralized with an aqueous 1N sodium hydroxide solution and then extracted with chloroform. The organic layer was washed with saturated saline and then dried over dried over anhydrous magnesium sulfate. After removing magnesium sulfate by filtration and concentrating under reduced pressure, the resulting crystal was washed with hexane and then dried to obtain 1.5 g of the objective 4-(4-imidazol-1-ylphenyl)-1,2,3,6-tetrahydropyridine (mp: 150-153° C.).

Provenance & Evidence