Hydrochloric Acid → HCID 23118289, compound

Participants

Reaction Steps

1.49 g of (±)-2-(5-nitro-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-ylmethyl)-2,3,4,9-tetrahydro-1H-beta-carboline, 2.49 g of stannous chloride, 11 ml of hydrochloric acid and 25 ml of ethanol were added and, after heating at reflux for 6.5 hours, the mixture was poured into ice-water and an aqueous sodium hydroxide solution was added. The reaction solution was extracted with chloroform, washed with saturated saline and dried over anhydrous magnesium sulfate and, after the solvent was distilled off under reduced pressure, the residue was purified by silica gel column chromatography (chloroform:methanol=100:3) to obtain 1.07 g of the objective product (melting point: 150-153° C.)

Provenance & Evidence