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9.5 g of 6-nitro-2-methoxymethyl-2,5,7,8-tetramethylchroman was dissolved in 80 ml of methylene chloride and 31.4 ml of a 1M boron tribromidemethylene chloride solution was added under a nitrogen gas flow at 0° C., followed by stirring at 0° C. for 3 hours. After the completion of the reaction, the reaction solution was poured into water and then extracted with chloroform. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. After removing magnesium sulfate by filtration and concentrating under reduced pressure, the residue was subjected to silica gel column chromatography (hexane:ethyl acetate=2:1) to obtain 4.5 g of the objective product.

1. customAfter the completion of the reaction
2. extractionextracted with chloroform
3. washThe organic layer was washed with saturated saline
4. dry with materialdried over anhydrous magnesium sulfate
5. customAfter removing magnesium sulfate
6. filtrationby filtration
7. concentrationconcentrating under reduced pressure