HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone → (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(6-morpholin-4-yl-pyridin-3-yl)-1H-indol-2-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Reactant | 6-(Morpholino)pyridine-3-boronic Acid (contains varying amounts of Anhydride) | HCID 46735167 | — |
| Product | (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(6-morpholin-4-yl-pyridin-3-yl)-1H-indol-2-yl]-methanone | HCID 16739630 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 2-morpholino-5-pyridine boronic acid. The title compound was obtained in 7% yield as yellow solid. MS (m/e): 568.4 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-4c2aa5e56d35437cacdc1e4643f999ef |
| Source note | uspto-grants-2010_06 |