反应详情

3-Mercaptopropan-1-ol (1.61 g, 17.4 mmol) was dissolved in acetone (40 mL) followed by addition of cesium carbonate (5.67 g, 17.4 mmol) and 3-bromo-dihydrofuran-2(3H)-one (1.63 ml, 17.4 mmol). The suspension was stirred vigorously for 40 hours. The reaction was filtered through silica gel, rinsed with acetone and concentrated in vacuo. The residue was chromatographed on silica gel eluting with 70-80% ethyl acetate/hexanes. Recovered the desired product as an oil (2.1 g, 71%).

1. filtrationThe reaction was filtered through silica gel
2. washrinsed with acetone
3. concentrationconcentrated in vacuo
4. customThe residue was chromatographed on silica gel eluting with 70-80% ethyl acetate/hexanes
5. customRecovered the desired product as an oil (2.1 g, 71%)