4-Nitrophenol → HCID 69066270, compound

Participants

Reaction Steps

To a solution of 4-nitrophenol (278 mg, 2.0 mmol) in DMF (6 mL) at room temperature under a nitrogen atmosphere was added powdered K2CO3 (552 mg, 2.0 mmol) followed by3-bromo-dihydrofuran-2-one (330 mg, 2.0 mmol). After stirring at room temperature under a nitrogen atmosphere for 16 hours, the mixture was diluted to 30 mL with EtOAc and washed with water (4×30 mL) and brine (30 mL). The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure to provide the product (240 mg, 54%) as tan oil that later solidified.

Provenance & Evidence