Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(4-(hydroxymethyl)phenylthio)dihydrofuran-2(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2(3H)-Furanone, 3-bromodihydro- | HCID 95463 | — |
| 반응물 | (4-Sulfanylphenyl)methanol | HCID 4677905 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(4-(hydroxymethyl)phenylthio)dihydrofuran-2(3H)-one | HCID 69071899 | 73.3% |
반응 단계
3-bromo-dihydrofuran-2(3H)-one (2.35 g, 14.3 mmol) was added to a solution of (4-mercaptophenyl)methanol (2.00 g, 14.0 mmol) and triethylamine (2.4 mmol, 17 mmol). The reaction was stirred at room temperature overnight, then was diluted with CH2Cl2 and washed sequentially with saturated NH4Cl and NaCl solutions. The organics were dried over MgSO4 and concentrated under reduced pressure to provide the product as a viscous oil (2.3 g, 72%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07553842B2 |
| 출처 데이터셋 | uspto-grants-2009_06 |
| ORD ID | ord-be28c555b33947a68fa454b43186ba49 |
| 출처 메모 | uspto-grants-2009_06 |