Hydrofluoric Acid → HCID 28561489, compound

Participants

Reaction Steps

A solution of 40% aqueous hydrofluoric acid in CH3CN (10 mL) was added to a 0° C. solution of (S)-3-(4-((tert-butyldimethylsilyloxy)methyl)phenoxy)-dihydrofuran-2(3H)-one in CH3CN (50 mL). The reaction was stirred for 30 minutes and then partitioned between a saturated NaHCO3 solution and diethyl ether. The organics were dried over MgSO4 and concentrated under reduced pressure. The residue was chromatographed to provide the desired product (0.92 g, 72%).

Provenance & Evidence