Chloroacetone → HCID 57725267, compound

HRID 1987833Notes

Reaction equation

HRID 1987833 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:21][C:22](=O)[CH3:23]>>[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:21]=[C:22]([CH3:23])[C:15]=2[C:16]([O:18][CH3:19])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 57725265HCID 57725265, compound

Product 1

HCID 57725267HCID 57725267, compound

Procedure

This compound is obtained according to the same procedure as the compound of Preparation III using the Tschitschibabin reaction, starting with 25.82 g of methyl 2-[3-(benzyloxy)pyridin-2-yl]acetate [according to J. Med. Chem.; (1996), 39(19), 3636-3658] and chloroacetone.

Workup

  1. customThis compound is obtained
  2. customthe Tschitschibabin reaction

Sources & evidence

ORD record
ord-ae653473eb4444228f254d8d88fd856b
Source dataset
uspto-grants-2009_06
Patent number
US07553845B2

Reaction notes

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