Chloroacetone → HCID 57725263, compound

HRID 1987834Notes

Reaction equation

HRID 1987834 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:21][C:22](=O)[CH3:23]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[N:13]([CH:21]=[C:22]([CH3:23])[C:15]=2[C:16]([O:18][CH3:19])=[O:17])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 57725266HCID 57725266, compound

Product 1

HCID 57725263HCID 57725263, compoundYield 69%

Procedure

This compound is obtained according to the same procedure as the compound of Preparation III using the Tschitschibabin reaction, starting with 19 g of methyl 2-[5-(benzyloxy)pyridin-2-yl]acetate [according to Bull. Pol. Acad. Sci. Chem.; (1990), 38(1-12), 17-27] and chloroacetone. 15.01 g of an orange-coloured solid are obtained.

Workup

  1. customThis compound is obtained
  2. customthe Tschitschibabin reaction

Sources & evidence

ORD record
ord-0e48adcdf3ab4d68ad4e6ce548c73a09
Source dataset
uspto-grants-2009_06
Patent number
US07553845B2

Reaction notes

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