m-Chloroperbenzoic acid → HCID 178488147, compound

Participants

Reaction Steps

125 g of omeprazole, obtained by oxidation with 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole with 3-chloroperoxybenzoic acid, were dissolved while stirring in a mixture of 62.5 ml of 40% of methylamine and 125 ml of dichloromethane at room temperature. To this clear solution was added 2000 ml of acetone, the combined solution was stirred for 1 hour at room temperature and thereafter cooled to a temperature in the range of −10 to −15° C. The product formed was filtered off, washed with acetone and dried in vacuo at room temperature to constant weight. Yield: 103.7 g (83%).

Provenance & Evidence