HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | methyl 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylate | HCID 67215533 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | 98% |
Reaction Steps
A 95:5 EtOH/H2O solution (5.0 mL) containing methyl 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylate (120 mg, 0.51 mmol) and NaOH (1.53 mol) was refluxed for 2 h whereupon the EtOH was removed in vacuum. After removal of traces of EtOH by azotroping twice with water, acidification to pH 3 with 1 M HCl generated a white precipitate. The precipitate was collected by filtration, washed with water, and dried in vacuum to give 110 mg (98%) of the title compound as a white solid. MS (ESI) 222 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553836B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-719eec87ee384b339fe1830edf9b7cd3 |
| Source note | uspto-grants-2009_06 |