HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → 4-(4-chlorophenyl)-N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | — |
| Reactant | 6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine | HCID 21939721 | — |
| Product | 4-(4-chlorophenyl)-N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrrole-2-carboxamide | HCID 67215214 | — |
Reaction Steps
Following preparation as described in WO03087046, 6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-amine was converted to the title compound (8 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. MS (ESI) 408 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553836B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-4b42eb2b1b674dde8e278147e21872f2 |
| Source note | uspto-grants-2009_06 |