4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → N-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-4-(4-chlorophenyl)-1H-pyrrole-2-carboxamide

HRID 1987904Notes

Reaction equation

HRID 1987904 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:16])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([C:29](O)=[O:30])[NH:27][CH:28]=2)=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:29]([C:26]2[NH:27][CH:28]=[C:24]([C:21]3[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=3)[CH:25]=2)=[O:30])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acidHCID 196269953-Chloro-4-[2-(pyrrolidin-1-yl)ethoxy]aniline

Product 1

HCID 67215310N-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-4-(4-chlorophenyl)-1H-pyrrole-2-carboxamide

Procedure

3-Chloro-4-(2-(pyrrolidin-1-yl)ethoxy)benzenamine was converted to the title compound (20 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid following the procedure described in step C of Example 1. MS (ESI) 444 (M+H)+.

Sources & evidence

ORD record
ord-1382181e6b7944198c93dbf43904efde
Source dataset
uspto-grants-2009_06
Patent number
US07553836B2

Reaction notes

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