4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67215172, compound

HRID 1987907Notes

Reaction equation

HRID 1987907 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[O:18][CH3:19])([CH3:4])([CH3:3])[CH3:2].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[C:30]([C:33](O)=[O:34])[NH:31][CH:32]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[C:30]([C:33]([NH:17][C:14]3[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][NH:7][C:6](=[O:20])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[C:12]([O:18][CH3:19])[CH:13]=3)=[O:34])[NH:31][CH:32]=2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acidHCID 58980844HCID 58980844, compound

Product 1

HCID 67215172HCID 67215172, compound

Procedure

tert-Butyl-(4-amino-2-methoxyphenoxy)ethylcarbamate was converted to the title compound (80 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. MS (ESI) 386 (M-Boc)+.

Sources & evidence

ORD record
ord-76d5b4789e87477da1e7acaa450ee7eb
Source dataset
uspto-grants-2009_06
Patent number
US07553836B2

Reaction notes

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