4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67215196, compound

HRID 1987910Notes

Reaction equation

HRID 1987910 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28](O)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28]([NH:1][C:2]3[CH:7]=[CH:6][C:5]([N:8]4[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]4)=[C:4]([O:14][CH3:15])[CH:3]=3)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acidHCID 67215346(3R)-1-(4-Amino-2-methoxyphenyl)pyrrolidin-3-ol

Product 1

HCID 67215196HCID 67215196, compound

Procedure

(R)-1-(4-amino-2-methoxyphenyl)pyrrolidin-3-ol, preparation described in Patent WO 2005/042541, was converted to the title compound (48 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (30 mg) following the procedure described in step C of Example 1. MS (ESI) 412 (M+H)+.

Sources & evidence

ORD record
ord-b49c4155f5c645ef824bf2b3283bf75a
Source dataset
uspto-grants-2009_06
Patent number
US07553836B2

Reaction notes

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