Hydrochloric Acid → 4-Bromo-2-phenoxybenzoic acid

Participants

Reaction Steps

Compound 5c (35.3 g, 129 mmol) was added to 130 mL EtOH, followed by the addition of 340 mL of 20% aqueous NaOH. The reaction was heated to reflux for 20 h. At that time the mixture was cooled to room temperature and poured into 6 N HCl. The solid was collected by vacuum filtration, dissolved in 3:1 THF-ethyl ether, and washed with brine. The organic phase was dried (MgSO4) and concentrated. The solids were dried in a vacuum oven at 60° C. overnight to give the desired compound 1b. MS m/z (MH+) 292.

Provenance & Evidence