3-(Chloromethyl)pyridine hydrochloride → HCID 58742383, compound

HRID 1988091Notes

Reaction equation

HRID 1988091 reaction equation
[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:25])[CH2:4]2)[CH3:2].Cl.[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33]Cl)[CH:28]=1>>[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([O:17][CH2:33][C:29]4[CH:28]=[N:27][CH:32]=[CH:31][CH:30]=4)=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:25])[CH2:4]2)[CH3:2]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 25258386HCID 25258386, compound

Product 1

HCID 58742383HCID 58742383, compound

Procedure

The title compound was prepared starting from the title product of Example 16 and 3-picolyl chloride hydrochloride using a procedure analogous to that outlined for Example 2. Product was isolated by flash chromatography eluting with 25% ethyl acetate in methylene chloride. Mass spectrum: m/e 430 (M+1).

Workup

  1. customProduct was isolated by flash chromatography
  2. washeluting with 25% ethyl acetate in methylene chloride

Sources & evidence

ORD record
ord-22f1f5821b824e2490c1e32a55ebe1c1
Source dataset
uspto-grants-2009_06
Patent number
US07553877B2

Reaction notes

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