3-(CHLOROMETHYL)-2-METHYLPYRIDINE HYDROCHLORIDE → HCID 58742356, compound

HRID 1988094Notes

Reaction equation

HRID 1988094 reaction equation
[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:26])[CH2:4]2)[CH3:2].Cl.Cl[CH2:29][C:30]1[C:31]([CH3:36])=[N:32][CH:33]=[CH:34][CH:35]=1>>[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([O:17][CH2:29][C:30]4[C:31]([CH3:36])=[N:32][CH:33]=[CH:34][CH:35]=4)=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:26])[CH2:4]2)[CH3:2]

Participants

3

Reactant 2

HCID 122437123-(CHLOROMETHYL)-2-METHYLPYRIDINE HYDROCHLORIDEHCID 58742312HCID 58742312, compound

Product 1

HCID 58742356HCID 58742356, compound

Procedure

The title compound was prepared starting from the title product of Example 28 and 3-chloromethyl-2-methylpyridine hydrochloride using the same procedure outlined for Example 2. Product was isolated by flash chromatography eluting with 35% ethyl acetate in hexane. Mass spectrum: m/e 462 (M+1).

Workup

  1. customProduct was isolated by flash chromatography
  2. washeluting with 35% ethyl acetate in hexane

Sources & evidence

ORD record
ord-7896fc3cd9504d47b7ab6406806e6bcb
Source dataset
uspto-grants-2009_06
Patent number
US07553877B2

Reaction notes

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