Chloroacetonitrile → HCID 68834040, compound

HRID 1988100Notes

Reaction equation

[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)([OH:18])[C@:5]([CH3:26])([OH:25])[CH2:4]2)[CH3:2].Cl[CH2:28][C:29]#[N:30]>>[CH2:1]([C@@:3]12[CH2:4][C@:5]([OH:25])([CH3:26])[C@:6]([OH:18])([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:7][C@H:8]1[CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([O:17][CH2:28][C:29]#[N:30])[CH:14]=[CH:15][C:16]2=1)[CH3:2]

Participants

Reactant 2

HCID 7856Chloroacetonitrile

HCID 10450738HCID 10450738, compound

Product 1

HCID 68834040HCID 68834040, compound

Procedure

The title compound was prepared from the compound of Example 102 according to the procedure of Example 57, running the reaction at room temperature overnight and using chloroacetonitrile as the alkylating agent. Mass spectrum (m/e) 393 (M+1).

Workup

customthe reaction at room temperature overnight

Sources & evidence

ORD record: ord-a5bfa8ce6d9147baae3464bff1086bbc
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07553877B2

Reaction notes

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