Hydroxylamine → HCID 86600606, compound

Participants

Reaction Steps

To a solution of 1-(4-chlorobenzoyl)-6-methyl-1,2-dihydroquinoline-2-carbonitrile (200 mg) in methanol (1 mL) was added cold 1M hydroxylamine in methanol (971 μL). The reaction mixture was warmed to ambient conditions and stirred overnight. The methanol is removed in vacuo and the crude product is purified by liquid chromatography (gradient elution of acetonitrile (0.02% trifluoroacetic acid)/water (0.02% trifluoroacetic acid) through a reverse phase C18 column) to give the titled compound (25 mg, 11% yield) as a pale yellow solid. (M+H)+−342.

Provenance & Evidence