Ammonia → HCID 178426205, compound

HRID 1988131Notes

Reaction equation

HRID 1988131 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:11][C@H:10]([N:12]3[CH2:16][CH2:15][CH2:14][CH:13]3[CH3:17])[CH2:9]2)=[CH:4][CH:3]=1.Br[C:19]1[CH:24]=[CH:23][C:22]([C@@H:25]2C[C@H](N3CCC[C@H]3C)C2)=[CH:21][CH:20]=1.[NH3:35]>>[CH3:17][CH:13]1[CH2:14][CH2:15][CH2:16][N:12]1[C@@H:10]1[CH2:11][C@H:8]([C:5]2[CH:6]=[CH:7][C:2]([C:19]3[CH:20]=[CH:21][C:22]([C:25]#[N:35])=[CH:23][CH:24]=3)=[CH:3][CH:4]=2)[CH2:9]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 178426204HCID 178426204, compoundHCID 178461415HCID 178461415, compound

Product 1

HCID 178426205HCID 178426205, compound

Procedure

The title compound was prepared using the procedure described in Example 2B except substituting the product from Example 3A for the product from Example 2A. 1H NMR (300 MHz, CD3OD) δ 1.22 (d, J=6 Hz, 3 H), 1.54 (m, 1 H), 1.84 (m, 2 H), 2.05 (m, 1 H), 2.19 (m, 2 H), 2.57 (m, 2 H), 2.71 (m, 2 H), 3.27 (m, 3 H), 7.39 (d, J=9 Hz, 2 H), 7.63 (d, J=9 Hz, 2 H), 7.79 (s, 4 H); (DCl/NH3) m/z 317 (M+H)+.

Sources & evidence

ORD record
ord-0eba9ef3bc364d4ba4c83d6042e5567f
Source dataset
uspto-grants-2009_06
Patent number
US07553964B2

Reaction notes

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